Thioredoxin reductase selenoenzyme

Thioredoxin reductases from mammalian cells are three selenoenzymes with a catalytically essential selenocysteine residue in the active site. The enzymes are critical for the function of the thioredoxin system in oxidative stress and other functions.

IMCO supplies recombinant rat thioredoxin reductase1 as the active selenoenzyme and at a price which is a fraction of what other companies charge. Only the authentic selenocysteine-containing enzyme (and not the cysteine mutant) is a target of many clinically used drugs.


New kit for high sensitivity GSH measurements

Measuring GSH in plasma and serum requires high sensitivity and is complicated by oxidation in samples upon storage. IMCO has developed a new kit for high sensitivity fluorescent determinations of GSH, GSSG and glutathionylated products.


Mammalian thioredoxin reductases: TR-03 and TR-03B

Mammalian thioredoxin reductase 1 (TrxR) contain an essential seleocycteine residue encoded by the stop codon UGA. This makes recombinant expression in E.coli a challenge. IMCO now has preparations of rat TrxR with unsurpassed specific activity.