Eosinglutathione as a fluorescent glutathione derivativee

Eosinglutathione has a high fluoresence whereas dieosinglutathione disulfide (DiEGSSG) is strongly quenched. This property combined with a negligable activity of DiEGSSG as a substrate for glutathione reductase is the basis for use in glutaredoxin assays.

The glutaredoxin assay kit FkGRX-01 kit determines glutaredoxin activity with oustanding sensitiviy.
DiEGSSG is also a product.


New kit for high sensitivity GSH measurements

Measuring GSH in plasma and serum requires high sensitivity and is complicated by oxidation in samples upon storage. IMCO has developed a new kit for high sensitivity fluorescent determinations of GSH, GSSG and glutathionylated products.


Mammalian thioredoxin reductases: TR-03 and TR-03B

Mammalian thioredoxin reductase 1 (TrxR) contain an essential seleocycteine residue encoded by the stop codon UGA. This makes recombinant expression in E.coli a challenge. IMCO now has preparations of rat TrxR with unsurpassed specific activity.