Oxidative stress by FkGRX-01

Oxidative stress results in oxidation of glutathione (GSH). Glutaredoxin ( Grx) uses the reductive power of GSH to reduce oxidized proteins. Grx1 is present in plasma and is a marker of oxidative stress (1). The FkGRX-01 kit measures Grx activity in 20-40 Ál of plasma.
1.Du, Y., Zhang, H., Montano, S., Hegestam, J., Ekberg, N.R., Holmgren, A., Brismar, K. and Ungerstedt, J.S.: Plasma glutaredoxin activity in healty subjects and patients with abnormal glucose levels or overt type 2 diabetes. Acta Diabetol. 51, 225-232, 2014.

FkGRX-01 (pdf, 165 kB)


New kit for high sensitivity GSH measurements

Measuring GSH in plasma and serum requires high sensitivity and is complicated by oxidation in samples upon storage. IMCO has developed a new kit for high sensitivity fluorescent determinations of GSH, GSSG and glutathionylated products.


Mammalian thioredoxin reductases: TR-03 and TR-03B

Mammalian thioredoxin reductase 1 (TrxR) contain an essential seleocycteine residue encoded by the stop codon UGA. This makes recombinant expression in E.coli a challenge. IMCO now has preparations of rat TrxR with unsurpassed specific activity.