Selenium in Mammalian Thioredoxin Reductase

Thioredoxin reductases (TrxR) from man and animal sources require an essential selenocysteine (Sec) residue in the active site for enzyme activity. IMCO produces recombinant enzyme with Sec inserted and this is used in products like TR-03, TR-03B or kTRX1-01. Also the FkTRX-02-V2 is based on active TrxR for reduction of Trx. Truncated enzyme with low specific activity and no Trx reducing activity is found on the market. For best results use IMCO products!

IMCO product list (pdf, 28 kB)


New kit for high sensitivity GSH measurements

Measuring GSH in plasma and serum requires high sensitivity and is complicated by oxidation in samples upon storage. IMCO has developed a new kit for high sensitivity fluorescent determinations of GSH, GSSG and glutathionylated products.


Mammalian thioredoxin reductases: TR-03 and TR-03B

Mammalian thioredoxin reductase 1 (TrxR) contain an essential seleocycteine residue encoded by the stop codon UGA. This makes recombinant expression in E.coli a challenge. IMCO now has preparations of rat TrxR with unsurpassed specific activity.