New Assay for thioredoxin reductase

Mammalian thioredoxin reductases are essential selenoproteins of great general interest for cancer research and oxidative stress diseases. IMCO has developed a new direct sensitive 96 well microplate assay using fluorescence based on thioredoxin disulfide reduction.
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FkTRXR-03 STAR 20131205.pdf (pdf, 176 kB)


New kit for high sensitivity GSH measurements

Measuring GSH in plasma and serum requires high sensitivity and is complicated by oxidation in samples upon storage. IMCO has developed a new kit for high sensitivity fluorescent determinations of GSH, GSSG and glutathionylated products.


Mammalian thioredoxin reductases: TR-03 and TR-03B

Mammalian thioredoxin reductase 1 (TrxR) contain an essential seleocycteine residue encoded by the stop codon UGA. This makes recombinant expression in E.coli a challenge. IMCO now has preparations of rat TrxR with unsurpassed specific activity.