New products 2010

IMCO has added six new products in 2010.These include human glutaredoxin 2, as product GRX-02, and a rabbit antibody against this protein, as product AGRX-02, which recognizes both human and mouse mitochondrial Grx2a. The polyclonal goat antibody against human Trx1 is now also available biotinylated as product ATRX-07. The pair of ATRX-03 and ATRX-07 may be used for ELISA applications with excellent results for determination of human Trx1. A new rabbit antipeptide antibody specific for full-length human Trx1 is available as ATRX-08. A mutant protein of E.coli glutaredoxin 1, Grx1C14S is sold as
GRX-04 and a mutant protein of E.coli Grx3, Grx3C14SC65Y is sold as GRX-05. Both these proteins act as specific protein deglutathionylation reagents together with GSH, NADPH and glutathione reductase.

The kits for highly sensitive enzymatic fluorescence assays in 96 well microtiter plates for thioredoxin, thioredoxin reductase and glutaredoxin will be available shortly.


New kit for high sensitivity GSH measurements

Measuring GSH in plasma and serum requires high sensitivity and is complicated by oxidation in samples upon storage. IMCO has developed a new kit for high sensitivity fluorescent determinations of GSH, GSSG and glutathionylated products.


Mammalian thioredoxin reductases: TR-03 and TR-03B

Mammalian thioredoxin reductase 1 (TrxR) contain an essential seleocycteine residue encoded by the stop codon UGA. This makes recombinant expression in E.coli a challenge. IMCO now has preparations of rat TrxR with unsurpassed specific activity.